Systems Aging

Aging is characterized by significant systemic changes such as altered metabolism, dysregulated hormone levels, and heightened inflammation. Driven by high resolution longitudinal profiling, research will focus on system studies of immune-aging and alterations in the endocrine system, their adverse impact on overall body health, the ability to fight infections, and response to therapeutics. Such knowledge can guide the development of drugs and vaccines tailored to individuals over the age of 60 and devise interventions to delay and reverse our systemic aging process.

This research theme is led by Asst. Prof. Noga Ron-Harel who is the head of the Immunometabolism and Aging Lab at the Technion. Her research group works on immune aging with a special focus on T lymphocytes, cells of the adaptive immune system that play a central role in the immune defense against intruders, mediate vaccination, and support tissue homeostasis and function.